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L M Neckers Selected Research

monorden (radicicol)

12/2001Stereospecific antitumor activity of radicicol oxime derivatives.
11/2000The heat shock protein 90 antagonist novobiocin interacts with a previously unrecognized ATP-binding domain in the carboxyl terminus of the chaperone.
9/2000Novel oxime derivatives of radicicol induce erythroid differentiation associated with preferential G(1) phase accumulation against chronic myelogenous leukemia cells through destabilization of Bcr-Abl with Hsp90 complex.

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L M Neckers Research Topics

Disease

4Neoplasms (Cancer)
01/2019 - 11/2000
2BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
09/2000 - 07/2000
1Breast Neoplasms (Breast Cancer)
12/2001
1Leukemia
10/2001
1Melanoma (Melanoma, Malignant)
02/2001

Drug/Important Bio-Agent (IBA)

5Proteins (Proteins, Gene)FDA Link
11/2012 - 07/2000
4geldanamycinIBA
12/2001 - 11/2000
3monorden (radicicol)IBA
12/2001 - 09/2000
2OximesIBA
12/2001 - 09/2000
1Protein Kinases (Protein Kinase)IBA
11/2012
1NucleotidesIBA
12/2001
1KF58333IBA
12/2001
1bcr-abl Fusion ProteinsIBA
10/2001
1beta CateninIBA
02/2001
1tyrosine receptor (receptor, tyrosine)IBA
02/2001
1Phosphoric Monoester Hydrolases (Phosphatases)IBA
02/2001
1Tyrosine (L-Tyrosine)FDA Link
02/2001
1Cadherins (E-Cadherin)IBA
02/2001
1Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA
02/2001
1Proteasome Endopeptidase Complex (Proteasome)IBA
02/2001
1Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
09/2000
1herbimycinIBA
07/2000
1Pyridinolcarbamate (P23)IBA
07/2000
1Rifabutin (Ansamycin)FDA Link
07/2000
1quinone (benzoquinone)IBA
07/2000

Therapy/Procedure

2Therapeutics
01/2019 - 11/2012
1Drug Therapy (Chemotherapy)
10/2001